Abstract
"Acute Hyperuricemia Secondary to Epileptic Seizures Leading to Acute Urate Nephropathy: A Case report"
Highlights
About two third of the body uric acid is produced endogenously while the rest of one third is from dietary products containing purines
This is a case of 35-year-old male with no premorbid who presented with generalized tonic clonic fits
After 2 days Renal function tests started deranging with maximum levels of Urea 55 mg/dl and creatinine 2.88 mg/dl
Summary
About two third of the body uric acid is produced endogenously while the rest of one third is from dietary products containing purines. Factors that predominantly effect uric acid excretion include tubular fluid Ph, tubular fluid flow rate and renal blood flow. Seizures is an exceedingly uncommon cause of acute hyperuricemia This is one such case of a patient with Generalized tonic clonic fits leading to acute hyperuricemia which in turn caused acute urate nephropathy. Chest was clear bilaterally with rest of respiratory examination normal. After 2 days his Renal function tests started deranging with Urea 45 mg/dl and creatinine 1.52 mg/dl. His previous renal function tests and uric acid were completely normal. Patient was managed with intravenous hydration and allopurinol His renal function tests and uric acid levels started declining and normalized after 5 days
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