Abstract
A 6-year-old girl with Sickle-cell disease was hospitalized because of fever and arthralgia. During hospitalization she developed a splenic sequestration with the need of three successive red packed-cell transfusions. Microbiological investigations revealed positive HPVB19 IgM and IgG and HPVB19 DNA in blood. Given the diagnosis of HPVB19 infection and persistent fever, she received intravenous immunoglobulins (IVIg) with progressive clinical improvement and discharge after 24 days of hospitalization. This is the first case of acute HPVB19 infection in a child with Sickle cell disease and more than 20 days fever, associated with splenic sequestration. IVIg may represent an effective therapy.
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