Abstract
The effects of intravenous SIN-1 (1 mg) and sublingual isosorbide dinitrate (ISDN) (5 mg) were studied in 12 patients with stable left ventricular failure (NYPHA class III-IV) secondary to ischemic, hypertensive, or idiopathic dilated cardiomyopathy. Data were collected during two periods separated by a washout phase, in a randomized, crossover, double-blind and double-placebo design. Heart rate was modified neither by SIN-1 nor by ISDN. A nonsignificant increase in cardiac output and decrease in aortic pressure were observed with both drugs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
