Abstract
Background: Milrinone (MIL) and nesiritide (NES) are vasoactive agents for decompensated heart failure (HF). Vascular and renal properties of NES are mediated via cGMP. High dose MIL increases cGMP, leading to possible synergistic effects. This study examined acute hemodynamic and renal effects of NES in pts with decompensated HF who were already on MIL. Methods: Charts of pts receiving NES in addition to MIL were reviewed. NES was added due to inadequate hemodynamic response to therapy. Patients receiving a stable dose of MIL>12 hrs before and >24 hrs after initiation of NES were studied.
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