Abstract
The effect of a partially purified fraction (T 1) and toxin γ purified from Tityus serrulatus scorpion venom, on gastric mucosa were investigated in anesthetized rats. The animals were injected i.v. with the T 1 fraction (37.5 μg/100g) or with saline and 60 min later were sacrificed and the stomachs resected. The gastric juice was measured and stereoscopic examination of the stomachs made. In animals injected with the T 1 fraction there was an increase in volume, acidity and pepsin output of rat stomach. The T 1 fraction also induced acute gastric injuries in the glandular mucosa, consisting of circular or linear ulcers, and punctiform lesions. Intravenous injection of 20 μg/100 g of a pure toxin obtained from Tityus serrulatus scorpion venom (toxin γ) also induced similar lesions in the rat stomach. Our data indicate that the injection of T 1 fraction or toxin γ are good models to induce acute gastric ulcers in a short period of time in anesthetized rats.
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