Abstract
BackgroundAcute fibrinous and organizing pneumonia (AFOP) is a very rare form of acute or subacute lung injury, which is characterized by patches of “fibrin balls” distributed within the alveoli.Given the lack of typical clinical manifestations, AFOP is often misdiagnosed as pneumonia, tuberculosis, etc. Definitive diagnosis is obtained from a lung biopsy. Corticosteroids are usually effective.Case presentationWe report two cases of patients with histopathological manifestations of AFOP, which were significantly improved after corticosteroid therapy. Previous reports of the clinical and pathological characteristics of AFOP were reviewed to improve clinicians’ understanding of this disease.ConclusionsEarly identification and diagnosis are very important for AFOP treatment. The prognosis is acceptable after timely and effective treatment.
Highlights
Acute fibrinous and organizing pneumonia (AFOP) is a very rare form of acute or subacute lung injury, which is characterized by patches of “fibrin balls” distributed within the alveoli
AFOP is a type of acute or subacute lung injury characterized by a dominant histological pattern of patchy intra-alveolar fibrin and organizing pneumonia, which does not meet the histological criteria for patterns of diffuse alveolar damage (DAD), organizing pneumonia (OP), or eosinophilic pneumonia (EP)
AFOP was histologically distinguished from DAD, bronchiolitis obliterans with organizing pneumonia (BOOP) and EP in the setting of acute lung injury
Summary
Acute fibrinous and organizing pneumonia (AFOP) is a very rare form of acute or subacute lung injury, which is characterized by patches of “fibrin balls” distributed within the alveoli. Definitive diagnosis is obtained from a lung biopsy due to the lack of other specific detection methodologies. After 1.5 months, a CT scan (Fig. 1g, h and i) showed that the bilateral lung lesions had absorbed more clearly than before, leaving only a few fibrous strands.
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