Abstract
AbstractTwo case reports are presented in which lithium and sulpiride were used jointly in patients with affective disorder. In both cases significant extrapyramidal reactions occurred. The reactions were successfully treated by withdrawing the drug combination. It is suggested that the adverse events relate to the mechanism of action of sulpiride which, unlike other neuroleptics, requires sodium to bind to the dopamine receptor. Lithium may substitute for sodiumenhancing sulpiride binding.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Human Psychopharmacology: Clinical and Experimental
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
