Abstract
Acute encephalopathy in a person with spinal cord injury and chronic renal failure, treated with high doses of thiamine
Highlights
Encephalic sufferance due to thiamine deficit is described in situation were an increased necessity of vitamin B1 happen
Thiamine diphosphate (TDP), the enzyme cofactor form of the vitamin, is synthesized from thiamine by the action of thiamine pyrophosphokinase, an enzyme which is directly inhibited by ethanol both in vitro and in vivo [1,2]
Activities of all three TDP-dependent enzymes are reduced in autopsied cerebellar tissue from alcoholic patients who died with neuropathologically confirmed Wernicke encephalopathy [4]
Summary
Encephalic sufferance due to thiamine deficit is described in situation were an increased necessity of vitamin B1 happen. Activities of all three TDP-dependent enzymes are reduced in autopsied cerebellar tissue from alcoholic patients who died with neuropathologically confirmed Wernicke encephalopathy [4] The products of these pathways are needed for the generation of other essential molecules involved in brain functioning. The rehabilitation project included: prevention of bedsores and deep vein thrombosis, increasing muscular tropisms (Functional Electrical Stimulation Cycling), maintaining joint excursions (passive physiokinetic therapy), increasing trunk control (active exercises), training of transferring from bed to wheelchair and utilization of wheelchair for independent mobility He spent 10 weeks for his rehabilitation and the several co-morbidities and the necessity of dialysis contribute to prolong the time as inpatient. He is followed as outpatient every six months and at last visit he was in stable clinical condition, continuing dialysis three times a week and maintaining, at home, passive physiokinetic therapy with cycle-ergometer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
