Abstract
Acute Encephalopathy and Pandemic (H1N1) 2009
Highlights
All 4 patients described in this case series had viral isolates containing H275Y mutation in the neuraminidase gene of pandemic (H1N1) 2009 virus, which is associated with high-level resistance to oseltamivir
Our observations suggest that oseltamivir-resistant pandemic (H1N1) 2009 virus is associated with poor prognosis and may retain the same tropism for lower respiratory tract involvement as wild type
We report a case in an adolescent patient with encephalopathy-associated pandemic (H1N1) 2009 that was confirmed by real-time RT-PCR of cerebrospinal fluid (CSF)
Summary
All 4 patients described in this case series had viral isolates containing H275Y mutation in the neuraminidase gene of pandemic (H1N1) 2009 virus, which is associated with high-level resistance to oseltamivir. Some data suggest that pandemic (H1N1) 2009 virus has a predilection to affect the lower respiratory tract and is associated with more illness and death than is seasonal influenza Our observations suggest that oseltamivir-resistant pandemic (H1N1) 2009 virus is associated with poor prognosis and may retain the same tropism for lower respiratory tract involvement as wild type.
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