Abstract
One hour after iv injection of rats with SU-4885, its reduced derivative SU-5236 or saline, the secretion rates (SR) of deoxycorticosterone (DOC), corticosterone, 18-hydroxydeoxycorticosterone (18-OH-DOC) and aldosterone, were measured in adrenal venous blood. Control rats had the following SR: DOC 10.0 ± 1.4, corticosterone 40.1 ± 6.1, 18-0H-D0C 20.3 ± 1.8 and aldosterone 0.50 ± 0.05 μg/hr/100 g body weight/2 adrenals (mean ± SE). Both SU-4885 and SU-5236, in doses of 20 and 5 mg/100 g body weight, inhibited the SR of corticosterone by 72 to 84%, the SR of 18-0H-D0C by 23 to 56% and increased the SR of DOC. Aldosterone was significantly decreased at these and lower dose levels. 1.2 mg/100 g of SU-5236 and SU-4885 did not have any effect on corticosterone or 18-OHDOC but they elevated DOC SR three fold (p < 0.001). SU-5236 was also effective at 0.3 mg (p < 0.01). Therefore, in high amounts, SU-4885 and SU-5236 inhibited the 11 β and 18 hydroxylases and increased DOC. In small doses, they stimulated DOC SR...
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