Abstract
Obesity promotes a state of chronic low-grade inflammation of white adipose tissue, which is associated with different chronic diseases. While exercise induces an anti-inflammatory environment, little is known about the acute effects of continuous exercise at different intensities on inflammatory markers in obese adolescents. This study included 10 obese adolescents of both sexes, between 15 and 18 years of age. Volunteers performed two 30-minute exercise sessions. The 1st exercise session was performed at moderate intensity (55% VO2peak) and the 2nd at vigorous intensity (75% VO2peak), with a one-week interval between sessions. Blood samples were collected 10 minutes before and 20 minutes after the exercise sessions. Inflammatory markers were analyzed using the chemiluminescence method. Statistical analysis was performed using the two-factors ANOVA test for repeated measures and statistical significance was set at 5% (p <0.05). The results showed that 30 minutes of moderate aerobic exercise resulted in significant changes in circulating levels of TNF-α (6.23 ± 1.64 to 7.03 ± 1.49) and IL-6 (3.35 ± 1.53 to 3.85 ± 1.73). The results of this study showed that a single exercise session of moderate intensity lasting for 30 minutes induced acute responses in inflammatory markers in the obese adolescents evaluated.
Highlights
RESUMO A obesidade promove um estado de inflamação crônica de baixo grau do tecido adiposo branco, o qual está associado a doenças crônicas
Evidence suggests that adipose tissue in excess results in increased levels of tumor necrosis factor (TNF-α), interleukin 6 (IL-6), leucocytes, and C-reactive protein (CRP), contributing to insulin resistance and endothelial dysfunction
Participants were recruited in schools and were required to meet the following inclusion criteria: aged between 15 and 18 and classified as obese according to the reference curves of the Centers for Diseases Control and Prevention (CDC)[6], Body mass index (BMI) ≥ 95th percentile
Summary
RESUMO A obesidade promove um estado de inflamação crônica de baixo grau do tecido adiposo branco, o qual está associado a doenças crônicas. Os resultados indicaram que 30 minutos de exercício aeróbico moderado resultou em mudanças significativas nos níveis circulatórios de TNF-α (6,23 ± 1,64 para 7,03 ± 1,49) e IL-6 (3,35 ± 1,53 para 3,85 ± 1,73). A partir dos resultados encontrados no presente estudo, pode-se concluir que uma única sessão de exercício físico de intensidade moderada com 30 minutos de duração induziu respostas agudas nos marcadores inflamatórios nestes adolescentes obesos Palavras-chave: Atividade física; Citocinas inflamatórias; Obesidade. One of the main concerns related to obesity is the presence of a state of chronic lowgrade inflammation in white adipose tissue. This adipose tissue, in particular the visceral type, synthesizes and secretes biologically active substances. Inflammatory condition may be reversible with weight reduction and/or regular physical exercise practice, which has been shown to modulate immune function and anti-inflammatory effects[6,7]
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