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Abstract
AbstractThe present studies were conducted to investigate the concentration-response characteristics of acute ozone (O3) exposure on the cardiovascular and thermoregulatory function of the unanesthetized, unrestrained rat, and to examine the modulating effects produced by changes in ambient temperature (T a) on the induced toxic response. For all studies, groups of male Fischer 344 rats (n - 4-6/group) were implanted with radiotelemetry transmitters and allowed to recover overnight. The transmitters permitted continuous monitoring of electrocardiogram (ECG) and body core temperature (T co); heart rate (HR) was derived from the ECG signal. Frequency of breathing (f) was obtained in selected experiments using a barometric plethysmograph. All animals were monitored according to the following protocol: control (filtered air, 0.25 hr); exposure (O3, 2 hr); recovery (filtered air, 3–18 hr). For the concentration-response experiments, O3 concentration was varied from 0.25 to 1.0 ppm and all exposures were conduc...
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