Abstract
Abstract: Locomotor activity measured by photocell actometers was taken as an index of behavioral arousal in rats following acute administration of pentazocine, morphine, methadone, levorphanol, and meperidine. The intraperitoneal doses tested were 1.25, 2.5, 5.0, 10, and 20 mg./kg. The low doses of morphine and methadone and an intermediate dose of pentazocine produced an early (1st hr.) increase in motility. Higher doses of these three drugs and the lowest dose of levorphanol caused a delayed excitation (2nd-3rd hr.). An early inhibition of activity was seen for the higher doses of morphine, methadone, meperidine, and levorphanol but not for pentazocine. Meperidine did not elicit significant locomotor excitation in these doses. The enhanced motility after pentazocine and the narcotic analgesics was blocked by pretreatment with α-methyltyrosine
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