Abstract
L, Carnitine (1000 mg) was given intravenously to nine subjects by perfusion lasting four hours. Its effects on plasma levels of Cholesterol, Triglycerides, FFA and B-OH-B were recorded and compared with the effects in the same subjects of a saline solution infusion. Following L, Carnitine a significant drop of FFA was observed 60 minutes after starting infusion while a maximum was reached four hours later. B-OH-B rose significantly at 60′ reaching a plateau which remained unmodified up to the 4th hour. No variations were observed in cholesterol and triglycerides plasma levels. The present data stress the view that Carnitine activates the carnitine acyltransferase system inducing an increased FFA oxidation and a consequential decrease of FFA plasma levels. At the same time, there is an increased production of ketone bodies and of their plasma levels. The shift of energy yielded by FFA oxidation from triglyceride synthesis to ketone body production may be a mechanism of a claimed lipid lowering effect of Carnitine.
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