Abstract

Electronic cigarette (e-cigarette) use is constantly increasing. However, the association between e-cigarette use and ventricular arrhythmia is unknown. Thus, in this study, we aimed to evaluate the markers of ventricular repolarization such as QT interval, corrected QT (QTc), QT dispersion (QTd), peak-to-end interval of the T wave (Tp-e), corrected Tp-e and Tp-e/QT ratios in e-cigarette users. The study population consisted 36 e-cigarette users and 40 healthy subjects. Ventricular repolarization parameters were obtained from 12-lead resting electrocardiogram. Ventricular repolarization parameters of the groups were compared. Basal demographic and laboratory data were similar in both groups. According to the electrocardiographic parameters, the Tp-e interval, corrected Tp-e, and Tp-e/QT ratio were significantly higher in individuals using e-cigarettes than in control subjects [74.9±6.4 milliseconds (ms) vs. 80.1±4.1ms, <0.001; 82.9±7.5 ms vs. 87.8±6.3 ms, p=0.003; 0.20±0.01 vs. 0.21±0.01, p=0.002; respectively]. This is the first study to show the disruption of ventricular repolarization properties in e-cigarette users. E-cigarette use in terms of public health leads to augmentation of transmural dispersion of repolarization, which may be potential indicator of ventricular arrhythmogenesis.

Highlights

  • The effects of conventional cigarette on cardiovascular system have been extensively studied with numerous studies in adults

  • Various methods such as ventricular repolarization, QT interval, QT dispersion (QTd) and transmural dispersion of repolarization have been used for this purpose

  • The purpose of this study was to evaluate the acute effects of e-cigarette use on ventricular repolarization parameters [QT interval, corrected QT (QTc), QT dispersion (QTd), peak-to-end interval of the T wave (Tpe), corrected Tp-e and ve Tp-e/QT ratios]

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Summary

Introduction

The effects of conventional cigarette on cardiovascular system have been extensively studied with numerous studies in adults. Electrocardiography (ECG) parameters have been recommended to be used in cardiovascular risk screening independently from conventional cardiovascular risk factors in middle age group[5]. Various methods such as ventricular repolarization, QT interval, QT dispersion (QTd) and transmural dispersion of repolarization have been used for this purpose. In this study, we aimed to evaluate the markers of ventricular repolarization such as QT interval, corrected QT (QTc), QT dispersion (QTd), peak-to-end interval of the T wave (Tp-e), corrected Tp-e and Tp-e/QT ratios in e-cigarette users. E-cigarette use in terms of public health leads to augmentation of transmural dispersion of repolarization, which may be potential indicator of ventricular arrhythmogenesis.

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