Abstract
Blood samples were taken every 5 min for a 3-h period from ovariectomized (OVX) adult rats bearing chronic venous catheters. After 1 h of sampling, an experimental drug was injected through the sampling catheter. The neuroleptics, chlorpromazine and haloperidol, blocked pulsatile discharges of luteinizing hormone (LH) in some animals, for periods of 65-120 min, as did the alpha-adrenergic receptor blockers, phenoxybenzamine and phentolamine. Pimozide, a more specific dopaminergic blocking agent, had less effect, while neither the beta-adrenergic receptor blocker, propranolol, nor the control treatments had any influence on the pulsatile LH patterns. The temporal pattern of inhibition of pulsatile discharges of LH by these drugs is more rapid than the inhibition caused by estrogen treatment in the OVX rat. These results suggest the presence of alpha, but not beta, adrenergic elements in the pulsatile mode of LH release in the OVX rat. They do not support the presence of dopaminergic elements, but neither do they conclusively deny it.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
