Abstract
1. Acute effects of human PTH-(1–34) fragment on blood pressure were examined in rats fed a low or normal calcium diet. 2. Plasma biochemistry showed that a low calcium diet evoked hyperparathyroidism as well as hypocalcemia in rats. 3. Subcutaneous administration of human PTH-(1–34) caused a significant decrease in tail-cuff systolic blood pressure in rats fed a normal calcium diet, but not in rats fed a low calcium diet. 4. Intravenous administration of human PTH-(1–34) reduced the arterial blood pressure in rats, dose-dependently. The reduction of blood pressure was more pronounced in rats fed a normal calcium diet than that in the rats fed a low calcium diet. 5. It is suggested that the hypotensive action of human PTH-(1–34) was more pronounced in the rats fed a normal diet than in the rats fed a low calcium diet, and that PTH has different cardiovascular consequences under chronic hyperparathyroidism and/or hypocalcemia.
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