Abstract
Design of the Study: Clinical Trial. Objective (s): To analyze the acute effect of aerobic exercise at different intensities in mucociliary clearance in patients with COPD, and to investigate possible associations of the autonomic nervous system in this response. Methods: 22 COPD patients underwent an initial evaluation for collecting personal data and spirometry to assess lung function. It was performed a progressive treadmill test for aerobic exercise prescription. Finally two randomized sessions of aerobic exercise with intensity of 60 % and 90 % of peak speed reached during the incremental test ( vVO2peack ) were performed with at least 24 hours of rest between them. The mucociliary clerance was assessed before and after the exercise sessions by testing the saccharin transit time (STT). Assessment of autonomic modulation was performed by heart rate variability (HRV) which continued throughout the protocol. Results: The values obtained in the STT test after aerobic exercise at 60 % of vVO2peack (9,08 minutes ± 4,96 ) was lower when compared to the STT before exercise ( 11,96 ± 6,31, p = 0,005 ) . That response also occurred after aerobic exercise at 90% of vVO2peack ( 8,90 ± 4,21 min ) compared to baseline ( 12,94 ± 7,22 , p = 0,023 ). Correlation analysis between the final values of STT test and HRV indexes did not show significant differences. Conclusions: Patients with COPD showed acceleration of mucociliary clerance right after a session of aerobic exercise. It was not possible to observe the association of autonomic modulation in this response
Highlights
As sessões de exercício realizadas a intensidade de 90% foram interrompidas sempre que os pacientes atingissem a exaustão voluntária, portanto nem sempre os pacientes foram capazes de realizar 30 minutos de exercício aeróbio em alta intensidade devido á dispneia e/ou cansaço nos membros inferiores
Para comparação dos valores de trânsito da sacarina (TTS) antes e após exercício aeróbio em cada intensidade, foi utilizado teste t de Student para dados pareado ou teste de Wilcoxon de acordo com a normalidade dos dados apresentada
O presente estudo possuiu como limitação os diferentes tempos de execução no protocolo de exercício aeróbio de alta intensidade (90%), já que os pacientes não conseguiram permanecer o tempo estipulado (30 minutos) devido à dispneia intensa ou cansaço em membros inferiores
Summary
Objetivo(s) do estudo: Analisar o efeito agudo do exercício aeróbio em diferentes intensidades no transporte mucociliar de pacientes com DPOC, bem como investigar possíveis associações do sistema nervoso autônomo nesta resposta. O transporte mucociliar foi avaliado antes e após realização do exercício por meio do teste do tempo de trânsito da sacarina (TTS). Resultados: Os valores obtidos no teste de TTS dos pacientes com DPOC após exercício aeróbio a 60% da vVO2pico (9,08 ± 4,96 minutos) foi menor comparado ao TTS antes do exercício (11,96 ± 6,31; p = 0,005). 1. Discente do Departamento de Fisioterapia, Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista (UNESP). Correspondencia Marceli Rocha Leite Universidade Estadual Paulista (UNESP) Rua Roberto Simonsen 305 CEP: 19060-900. Medicina (Ribeirão Preto) 2015;48(6): 523-32 http://www.revistas.usp.br/rmrp / http://revista.fmrp.usp.br
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