Abstract
Acute Coronary Events in Patients with Myeloproliferative Newoplasms – Nationwide Analysis of Patient Characteristics and in Hospital Outcomes
Highlights
Myeloproliferative neoplasms (MPN) are characterized by clonal expansion of cells belonging to the erythroid and/or myeloid lineages
There was no significant difference in the in-hospital mortality in acute coronary syndromes (ACS) patients with or without MPN (5.83% vs 4.57% respectively, p = 0.59)
Patients with MPN had a higher risk of acute pulmonary embolism, cardiogenic shock, and acute kidney injury as well as increased length of stay and hospitalization costs (Table 1)
Summary
Myeloproliferative neoplasms (MPN) are characterized by clonal expansion of cells belonging to the erythroid and/or myeloid lineages. Concomitant platelet dysfunction and thrombocytosis predispose these patients to both arterial thromboses and bleeding, causing a high burden of morbidity and mortality. With advances in cancer therapeutics and improving survival, an increasing number of patients with MPN are presenting with acute coronary syndromes (ACS). Data regarding in-hospital outcomes and revascularization strategies utilized in these patients is limited, due to lack of representation in trials and rarity of the disease
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