Acute CMV Hepatitis in a Healthy Adult

Abstract

Cytomegalovirus infection is a commonly seen infection in the world, and rate of adults experiencing this infection reaches up to 90% in developing countries. The infection limits itself in healthy population, being symptomatic in 10% of them. Although symptomatic cases usually present as mononucleosis-like syndrome, they rarely cause organ specific complications. In this article, we present a case of acute, severe cytomegalovirus infection manifesting as persistent high fever, elevations of aspartate aminotransferase and alanin aminotransferase, high INR, thrombocytopenia, hepatomegaly, and splenomegaly in 40 year old immunocompetent adult. The patient was diagnosed as cytomegalovirus hepatitis and given gancyclovir 2x250 mg IV for 14 days. He was discharged upon the improvement of his general status, development of seroconversion and decline of liver enzymes. This case was presented to highlight that cytomegalovirus must be taken into consideration in etiology of hepatitis. Key Words: Cytomegalovirus Ýnfection; Hepatitis; Ýmmunocompetent Adult.