Acute clinical and financial outcomes of on- versus off-pump coronary artery bypass grafting in octogenarians

Abstract

BackgroundCoronary artery bypass surgery in octogenarians is associated with increased postoperative morbidity. Off-pump coronary artery bypass surgery eliminates potential complications of cardiopulmonary bypass, but its use remains controversial. This study aimed to evaluate the clinical and financial impact of off-pump coronary artery bypass surgery compared to conventional coronary artery bypass surgery among this high-risk population. MethodsPatients ≥80 years undergoing first-time, isolated, elective coronary artery bypass surgery were identified using the 2010–2019 Nationwide Readmissions Database. Patients were grouped into off-pump or conventional coronary artery bypass surgery cohorts. Multivariable models were developed to assess the independent associations between off-pump coronary artery bypass surgery and key outcomes. ResultsOf ∼56,158 patients, 13,940 (24.8%) underwent off-pump coronary artery bypass surgery. On average, the off-pump cohort was more likely to undergo single-vessel bypass (37.3 vs 19.7%, P < .001). After adjustment, undergoing off-pump coronary artery bypass surgery was associated with similar odds of in-hospital mortality (adjusted odds ratio 0.90, 95% confidence interval 0.73–1.12) relative to conventional bypass. Additionally, the off-pump and conventional coronary artery bypass surgery groups were comparable in odds of postoperative stroke (adjusted odds ratio 1.03, 95% confidence interval 0.78–1.35), cardiac arrest (adjusted odds ratio 0.99, 95% confidence interval 0.71–1.37), ventricular fibrillation (adjusted odds ratio 0.89, 95% confidence interval 0.60–1.31), tamponade (adjusted odds ratio 1.21, 95% confidence interval 0.74–1.97), and cardiogenic shock (adjusted odds ratio 0.94, 95% confidence interval 0.75–1.17). However, the off-pump coronary artery bypass surgery cohort was linked with an increased likelihood of ventricular tachycardia (adjusted odds ratio 1.23, 95% confidence interval 1.01–1.49) and myocardial infarction (adjusted odds ratio 1.34, 95% confidence interval 1.16–1.55). Furthermore, those undergoing off-pump coronary artery bypass surgery demonstrated reduced odds of non-home discharge (adjusted odds ratio 0.91, 95% confidence interval 0.83–0.99) and a decrement in hospitalization expenditures ($-1,290, 95% confidence interval –$2,370 to $200). ConclusionOff-pump coronary artery bypass surgery was linked with increased odds of ventricular tachycardia and myocardial infarction, but no difference in mortality. Our findings point to the safety of conventional coronary artery bypass surgery in octogenarians. Yet, future work is needed to consider long-term outcomes in this complex surgical cohort.