Abstract
Augmentation index (AI) is used as a measure of arterial stiffness. It represents the augmentation in central aortic pressure due to the effect of returning reflected pulse wave. The aim of the study was to assess the relationship between acute changes in renal vascular resistance (RVR) and arterial stiffness (assessed by AI) during static exercise. Nine subjects (mean age 31.7±9.1 years, 5 males) performed two protocols: First, handgrip (HG) for 15 sec at 30% and 70% of maximum voluntary contraction (MVC). Second, HG to fatigue (HGF) at 40% of MVC followed by post handgrip circulatory arrest (CA) for 2 min. RVR was calculated as the quotient of blood pressure (beat-by-beat) to renal artery velocity (Duplex). AI% was computed by the SphygmoCor software from the aortic pressure waveform, derived from the radial artery waveform recorded by a micromanometer. The AI% was logarithmically transformed and corrected for heart rate. Results: Table 1. The increase in Log AI% accompanied by increase in RVR index was more pronounced in the HGF and CA protocol. Conclusion: During static exercise, renal vascular resistance and arterial stiffness (measured by augmentation index) increase in a parallel way reflecting sympathetic activation. Supported by P01 HL077670.
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