Abstract
BackgroundAccording to previous meta-analyses, coffee consumption reduces the risk of type 2 diabetes mellitus. However, the underlying mechanism remains unknown. Whether caffeine, the key ingredient in coffee, has a beneficial effect on the glycemic homeostasis and the anti-diabetic effect is particularly controversial. The aim of this study was to summarize the effect of acute caffeine ingestion on insulin sensitivity in healthy men.MethodsA comprehensive literature search for papers published before April 2016 was conducted in EMBASE, PubMed, and Cochrane Library databases. Randomized controlled trials (RCTs) that investigated the effect of caffeine on insulin sensitivity in healthy humans without diabetes were included. A random effects meta-analysis was conducted using Review Manager 5.3.ResultsThe search yielded 7 RCTs in which caffeine intake was the single variant. Compared with placebo, caffeine intake significantly decreased the insulin sensitivity index, with a standardized mean difference of −2.06 (95% confidence interval −2.67 to −1.44, I2 = 49%, P for heterogeneity = 0.06).ConclusionAcute caffeine ingestion reduces insulin sensitivity in healthy subjects. Thus, in the short term, caffeine might shift glycemic homeostasis toward hyperglycemia. Long-term trials investigating the role of caffeine in the anti-diabetic effect of coffee are needed.
Highlights
The worldwide prevalence of type II diabetes has doubled in the previous two decades; this, in combination with the high disability and mortality rates has contributed to the serious effects of type II diabetes on human health [1]
Kemfp et al reported that coffee consumption might have beneficial effects on subclinical inflammation and high-density lipoprotein cholesterol [19]
Search strategy The PubMed (1960 to April 2016; http://www.ncbi.nlm. nih.gov/pubmed/), EMBASE (1980 to April 2016; http:// www.embase.com/), and Cochrane Library (1985 to April 2016; http://www.cochrane.org/) databases were searched for Randomized controlled trials (RCTs) that examined the effects of caffeine on insulin sensitivity in healthy humans
Summary
The worldwide prevalence of type II diabetes has doubled in the previous two decades; this, in combination with the high disability and mortality rates has contributed to the serious effects of type II diabetes on human health [1]. Prevention of diabetes through the adoption of healthy dietary habits is important for the effective management of hyperglycemia [3, 4]. Various mechanisms have been proposed regarding the protective effect of long-term coffee consumption against type II diabetes. Kemfp et al reported that coffee consumption might have beneficial effects on subclinical inflammation and high-density lipoprotein cholesterol [19]. According to previous meta-analyses, coffee consumption reduces the risk of type 2 diabetes mellitus. The key ingredient in coffee, has a beneficial effect on the glycemic homeostasis and the anti-diabetic effect is controversial. The aim of this study was to summarize the effect of acute caffeine ingestion on insulin sensitivity in healthy men
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
