Acute biologic response to excimer versus thermal laser angioplasty in experimental atherosclerosis

Abstract

Vascular injury and platelet accumulation after balloon angioplasty are two potentially important triggers of the process of restenosis that may be minimized by the use of laser energy to ablate atherosclerotic plaque. The type of laser most suitable to achieve these goals remains unknown. Accordingly, angiographic and histologic studies and quantitative platelet deposition analysis were performed on 27 atherosclerotic rabbit iliac arteries randomized to treatment with excimer laser or thermal laser angioplasty. Excimer laser angioplasty was achieved with 35 to 40 mJ/mm2of 308 nm xenon chloride irradiation delivered through a 4.5F catheter made of 13 concentrically arranged 200 μm fiber optics, at a repetition rate of 25 to 30 Hz and a pulse duration of 135 ns; thermal laser angioplasty was achieved with a 1.7 mm metal probe heated with 10 W of continuous wave argon laser energy.The baseline and post-laser luminal diameters of excimer laser-treated vessels (0.92 ± 0.28 and 1.56 ± 0.48 mm, respectively) were similar to those observed in thermal laser-treated vessels (1.05 ± 0.44 and 1.61 ± 0.41 mm, respectively). Perforation occurred in 4 (29%) of 14 thermal laser-treated arteries and in 0 of 13 excimer laser-treated arteries (p = 0.04); spasm was observed in only 1 thermal laser-treated vessel. On the basis of a quantitative histologic grading scheme (damage scores of 0 to 4), greater degrees of injury were measured in thermal versus excimer laser-treated vessels (2.4 ± 1.0 versus 1.3 ± 0.4, p = 0.009). When arteries with vascular perforation were excluded, similar degrees of platelet deposition were seen in thermal and excimer laser-treated vessels (27 ± 22 and 17 ± 3 × 106platelets/ cm, respectively; p = 0.37). In vessels treated with thermal laser angioplasty, platelet deposition was strongly correlated with histologie gradc (r = 0.72; p = 0.006).These results suggest that the excimer laser is able to ablate atherosclerotic plaque in vivo with fewer complications and lower levels of histologic damage than are obtained with the thermal laser; however, in atherosclerotic vessels, excimer laser angioplasty does not reduce platelet deposition. Whether these effects of the excimer laser will translate into an increased or decreased rate of restenosis after angioplasty remains to be determined.