Abstract
Acute basophilic leukemia (ABL) is a very uncommon form of acute myeloid leukemia (AML), accounting for 4-5% of all cases of acute non-lymphocytic leukemia. Most cases have been described to evolve from other hematological diseases, such as chronic myeloid leukemia (CML) and myelodysplastic syndromes (MDS). CML is one of the classical types of myeloproliferative neoplasms (MPN), characterized by the existence of a reciprocal translocation between the chromosomes 9 and 22, t(9;22)(q34:q11), resulting in BCR-ABL1 fusion gene. The peripheral blood routine typically manifests with leukocytosis, but rarely with isolated marked thrombocytosis. Here, we report a rare case of ABL transformed from CML with isolated significant thrombocytosis.
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Schedule a callMore From: Turkish journal of haematology : official journal of Turkish Society of Haematology
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