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Abstract
BackgroundAppendiceal metastasis from lung cancer is rare. However, it often causes acute appendicitis that requires emergency surgery. We herein report a thought-provoking case of appendiceal metastasis from lung cancer.Case presentationA 71-year-old man was diagnosed with advanced lung cancer with multiple metastases and underwent chemotherapy. One month later, he developed acute appendicitis, and laparoscopic appendectomy was promptly performed. A swollen appendix and pus collection were observed during surgery. Histological analysis revealed an invasive adenocarcinoma in the appendix that infiltrated the mucosal, submucosal, and muscular layers. Positive immunostaining of thyroid transcription factor 1 indicated appendiceal metastasis of pulmonary adenocarcinoma, not a primary appendiceal malignancy. The postoperative course was uneventful, and the patient’s pulmonary internist resumed continuous chemotherapy after surgery.ConclusionsAlthough appendiceal metastasis from pulmonary adenocarcinoma is rare, it often results in acute appendicitis. Optimal therapy including emergency surgery should be performed without hesitation so that chemotherapy can be resumed as soon as possible.
Highlights
Appendiceal metastasis from lung cancer is rare
Conclusions: appendiceal metastasis from pulmonary adenocarcinoma is rare, it often results in acute appendicitis
Optimal therapy including emergency surgery should be performed without hesitation so that chemotherapy can be resumed as soon as possible
Summary
AA is a common disease worldwide, and primary appendiceal cancer often causes AA. secondary AA caused by appendiceal metastasis from LC is rare; the reported frequency of appendiceal metastasis of LC is. With respect to the histological findings of LC that develops appendiceal metastasis, seven cases of small cell carcinoma [7,8,9,10,11,12,13] and four cases of adenocarcinoma [4, 14–16] have been reported. Based on the immunopathological findings of TTF-1 immunostaining, we definitively diagnosed appendiceal metastasis from pulmonary adenocarcinoma, not a primary appendiceal cancer. Appendiceal metastases from LC are usually diagnosed only after AA has developed [7,8,9,10,11,12,13,14, 16], fluorodeoxyglucose position emission tomography is reportedly useful for detection of appendiceal metastasis [12]. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
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