Abstract
Epilepsy is one of the chronic neurological conditions affecting people of all ages globally. Educational progress have been affected negatively by some abnormalities associated with epilepsy. This study employed neurobehavioural analysis of pentylenetetrazole (PTZ) induced seizure on some visual spatial functions in Wistar rats. The study was done in two phases: acute (14days) and chronic (28days). A total of twenty adult Wistar rats weighing between 90-120g were used. The rats were divided into four (4) groups (1-4, n=5). PTZ was administered intraperitoneally to the PTZ treated groups one (1) week before the neurobehavioral experiments commenced. Group 1 (control) received distilled water, group 2, 3and 4 were administered with doses of PTZ (25mg/kg, 30mg/kg and 35mg/kg) respectively at alternate days (48 hourly) until kindling was achieved. The study evaluated neurobehavioural parameters using Barnes maze (BM), navigational box test (NBT). The results from neurobehavioural evaluations on effects of the chemo-convulsant seizures on visual spatial functions, suggests that severity of seizures caused a deficit in learning and visual spatial memory which was worsened by chronicity. In conclusion, PTZ-induced seizure negatively interferes with visual spatial functions.
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