Abstract
The effects of d- and 1-amphetamine were studied on different patterns of seizure activity in male mice, e.g., pentylenetetrazol-induced minimal (clonic) and maximal (tonic) seizures and low-frequency electroshock seizure threshold (1.f. EST). Acute administration of d- and 1-amphetamine increased susceptibility to minimal and 1.f. EST. Whereas 1-amphetamine increased maximal seizure susceptibility, the d-isomer decreased susceptibility to this seizure pattern. Daily injections of the amphetamine isomers for 7 consecutive days produced tolerance to all these changes in seizure threshold. d-Amphetamine was approximately twice as active as 1-amphetamine in altering seizure threshold. These studies are in agreement with the concept that amphetamine-enhanced pentylenetetrazol-induced seizures are mediated by dopamine. Chronic administration of saline for 7 days reduced susceptibility to maximal seizures and 1.f. EST 35 and 72%, respectively, but had little effect on minimal seizure threshold.
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