Abstract
SummaryA variety of conditions favoring the production of chronic forms of AE existed between the optimal conditions for acute AE (guinea pig antigen in adult Strain 13/N) and for strong resistance to AE (rabbit antigen in newborn Strain 2/N). The resistance of Strain 2/N guinea pigs to autoimmune encephalomyelitis is not absolute. Older Strain 2/N female guinea pigs regularly develop severe or lethal AE when sensitized with guinea pig spinal cord in Freund's complete adjuvant. Guinea pig spinal cord is a more potent encephalitogen than rabbit spinal cord in Strains 2/N and 13/N guinea pigs. Sensitized Strain 2/N guinea pigs of an age group showing no overt clinical signs of AE nevertheless showed striking histological lesions of AE in the central nervous system.
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