Abstract
The possibility that endogenous elevation of serotonin is influencing blood–/INS;brain barrier (BBB) permeability, neuronal nitric oxide synthase activity was examined in the brain and spinal cord of rats. Elevation of endogenous serotonin level was achieved by administration of its precursor, 5-hydroxytryptophan (150mg/kg, i.p.). The elevation of serotonin level in the brain and spinal cord was confirmed by immunohistochemical demonstration of 5-HT activity. Four hours/INS; after administration of 5-HTP, the animals exhibited hyperthermia and other behavioral symptoms.
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