Abstract
Abstract Magnetic actuation of medical devices is of great interest in improving minimally invasive surgery and enabling targeted drug delivery. With untethered, magnetically coated swimmers it is aimed at reaching regions of the body difficult to access with catheters. Such a swimmer was previously presented, which is suitable for the navigation by the magnetic fields of a magnetic particle imaging (MPI) scanner. The swimmer could be imaged with MPI as well, enabling the tomographic real-time tracking of the actuation process. In this work the steerability of the swimmer is further investigated in media of varying viscosities. For this, glycerol-water-mixtures of different mixing ratios were used. The velocities of the swimmer were measured for viscosities between those of pure glycerol and pure water. The experiments were performed with an MPI scanner at maximal magnetic field strength of the actuating fields. A viscosity range was found in which the swimmer is steerable by the fields of an MPI scanner, which leads to a prediction of the applicability of the swimmer in different body fluids.
Highlights
The actuation of medical devices with magnetic fields is under investigation
This technique has the potential to improve the precision of minimally invasive surgery, enables targeted drug delivery and has the potential to be used for local hyperthermia
Between 83 mPa∙s and 26 mPa∙s the swimmer reacts to the magnetic field, but does not fulfil full rotation
Summary
The actuation of medical devices with magnetic fields is under investigation. It enables the untethered steering of helically shaped swimmers providing the opportunity to reach areas of the body difficult to access. This technique has the potential to improve the precision of minimally invasive surgery, enables targeted drug delivery and has the potential to be used for local hyperthermia. An MPI scanner provides magnetic fields which cannot only be used for the visualization of magnetic nanoparticles, and for magnetic actuation by using homogeneous rotating magnetic fields [1,6]. MPI is a three-dimensional, real-time imaging technique, without ionizing radiation; MPI has a high potential for interventional and vascular imaging [8,9,10]
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