Abstract
Sensory information is continuously processed so as to allow behavior to be adjusted according to environmental changes. Before sensory information reaches the cortex, a number of subcortical neural structures select the relevant information to send to be consciously processed. In recent decades, several studies have shown that the pathophysiological mechanisms underlying movement disorders such as Parkinson's disease (PD) and dystonia involve sensory processing abnormalities related to proprioceptive and tactile information. These abnormalities emerge from psychophysical testing, mainly temporal discrimination, as well as from experimental paradigms based on bodily illusions. Although the link between proprioception and movement may be unequivocal, how temporal tactile information abnormalities and bodily illusions relate to motor disturbances in PD and dystonia is still a matter of debate. This review considers the role of altered sensory processing in the pathophysiology of movement disorders, focusing on how sensory alteration patterns differ between PD and dystonia. We also discuss the evidence available and the potential for developing new therapeutic strategies based on the manipulation of multi-sensory information and bodily illusions in patients with these movement disorders.
Highlights
A large body of evidence shows that altered sensory processing intervenes in the pathophysiology of movement disorders, including Parkinson’s disease (PD) [for a review see [1]] and dystonia [for a review see [2]]
The fact that sensory abnormalities are consistently present in patients which clinically manifest motor disturbances has raised the question whether sensory alterations participate in the pathophysiological mechanisms of motor disturbances in PD and dystonia through defective sensorimotor integration
It is still unknown whether the pattern of proprioceptive and tactile abnormalities and the pattern of bodily illusion alterations is similar in PD and dystonia
Summary
A large body of evidence shows that altered sensory processing intervenes in the pathophysiology of movement disorders, including Parkinson’s disease (PD) [for a review see [1]] and dystonia [for a review see [2]]. The fact that sensory abnormalities are consistently present in patients which clinically manifest motor disturbances has raised the question whether sensory alterations participate in the pathophysiological mechanisms of motor disturbances in PD and dystonia through defective sensorimotor integration. It is still unknown whether the pattern of proprioceptive and tactile abnormalities and the pattern of bodily illusion alterations is similar in PD and dystonia. In this narrative review, we examine the evidence on actual and illusory sensory perception in PD and dystonia and discuss the possible role of these abnormalities in the pathophysiology of movement disorders
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