Abstract
BACKGROUND Disulfiram has promising preclinical activity against glioblastoma (GBM) as well as synergy with temozolomide. In a phase I study for newly diagnosed GBM after chemoradiotherapy, we have previously shown the maximum tolerated dose (MTD) of disulfiram with adjuvant temozolomide is 500mg per day (QD). Here we report the updated results of the phase I study with a dose-expansion cohort with the addition of concurrent copper gluconate supplement.
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