Abstract
Acylated pentapeptide XPhePheGlyLeuMetNH 2 analogs of the substance P (7–11) sequence were synthesized by solution method and their spasmogenic activities were evaluated on guinea pig ileum (GPI) and trachea (GPT). Pentapeptide SP(7–11) had the lowest potency and its N-acylation increased its activity in both tests, with some derivatives being more active than SP itself. Results obtained on GPI suggest a close dependence of activity upon structural factors in the vicinity of the Phe 7 N-terminus, whereas the activity on GPT seems more dependent upon the hydrophobicity of the analogs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
