Abstract
We have synthesized and investigated structural and functional properties of plasmid DNA complexes with multi-walled carbon nanotubes (MWCNTs) for detection of changes in structural state of the plasmid DNA at its recognition by site-specific endonuclease. It has been also established that the site-specific endonuclease is functionally active on the surface of MWCNTs.
Highlights
И Study of nuclease activity is important for understanding reasons of variability of deoxyribonucleicacid (DNA) structure
The development of nanosensors for biochemical markers is constrained due to low sensitivity of nuclease activity detection. One solution to this problem is the use of multi-walled carbon nanotubes (MWCNTs), possessing unique electrophysical properties and biocompatibility [4]
Development of DNA-nanosensors based on complexes of DNA/carbon nanotube (DNA/CNT), which are designed for express DNA-diagnosis by changing of the structural state of nucleic acids under the action of nucleases, is relevant
Summary
This content has been downloaded from IOPscience. Please scroll down to see the full text. View the table of contents for this issue, or go to the journal homepage for more. Й This content was downloaded on 22/09/2016 at 13:38 РЕПОЗИТОРИ Please note that terms and conditions apply. V P Egorova, H V Krylova, I V Lipnevich, A A Veligura, B G Shulitsky, БГПУ A A Asayonok, E V Vaskovtsev. We have synthesized and investigated structural and functional properties of plasmid. DNA complexes with multi-walled carbon nanotubes (MWCNTs) for detection of changes in. И structural state of the plasmid DNA at its recognition by site-specific endonuclease.
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