Activity of neuron-specific enolase in patients with acute ishemic stroke on the background of correction of infusion solutions

Abstract

The article analyzes the impact of a single course of treatment with various infusion solutions on the intensity of the flow of destructive changes in the neurons of the brain to the dynamics of the activity of the neuron-specific enolase, which is an early marker of damage of the nervous tissue. The level of neuron-specific enolase in serum of patients with acute stroke is correlated with the volume of cerebral infarction. To a thorough determine the presence of the protective effect in the infusion solutions on the brain was interest to investigate the effect of a single course of treatment with various solutions on the intensity of the flow of destructive changes in the neurons of the brain with the dynamics of neuron-specific enolase in acute disorder of cerebral circulation. Analyzed isoosmolar 0.9% NaCl solution and colloidal isoosmolar hydroxyethylstarch 130/04 solution administered intravenous drip in a conventionally effective dose of 2.5 ml / kg p 2 / day (5 ml / kg per day) (determined experimentally) immediately upon confirmation of the diagnosis and further a daily basis and every 12 h for 7 days. Control group were patients treated with infusion solutions only 0.9% NaCl, control group – 0.9% NaCl + hydroxyethylstarch 130/04. Using of the isoosmolar 0.9% NaCl solution for 7 days in addition to standard therapy promotes a statistically significant increase in the activity of the neuron-specific enolase on the seventh day of stroke, which is associated with increasing of necrotic tissue in the ischemic area of the brain in patients with acute disorder of cerebral circulation in ischemic type. Infusion therapy in patients with acute disorder of cerebral circulation in ischemic type with isoosmolar 0,9% NaCl + colloid isoosmolar solution of hydroxyethyl starch 130/04, against a background of standard therapy, been accompanied by a significant decrease in the neuron-specific enolase compared with the control group which indicates the presence in hydroxyethyl starch 130/04 corrective influence on the dynamics of the processes of neuronal death in acute ischemic stroke. A possible mechanism of protective effect of hydroxyethyl starch 130/04 implemented by improving perfusion of the penumbra, the disclosure of collaterals, properties of endothelial protection in acute disorder of cerebral circulation.