Activity of compound G2 isolated from alfalfa roots against medically important yeasts

Abstract

Screening of various vegetables as biocatalysts for the stereoselective bioreduction and resolution of racemic bicyclo[3.3.1]nonane-2,6-dione was performed. Vegetables of the family Apiaceae, i.e. the roots of parsnip (Pastinaca sativa), celery (Apium graveolens), parsley (Petroselinum crispum) and carrot (Daucus carota) were found to be the best. The methodology described here allows the efficient enantioseparation of (+)-enantiomer of bicyclo[3.3.1]nonane-2,6-dione. The reaction time, temperature and the amount of celery roots were optimized and (+)-enantiomer was obtained with the optical purity of 90–98% and the yield of more than 90%.