Activity guided isolation and characterization of bioactive constituents from Mucuna pruriens

Abstract

There are roughly 150 species of annual and perennial legumes in the genus Mucuna, which belongs to the Fabaceae family, subfamily Papilionaceae. The velvet bean Mucuna pruriens is widespread in tropical and sub-tropical parts of the world, and is one of the many undervalued wild legumes. Velvet bean, Florida velvet bean, Bengal velvet bean, Mauritius velvet bean, Yokohama velvet bean, cowhage, cowitch, lacuna bean, and Lyon bean are some of the other frequent names for this unusual plant. Atmagupta, which means "hidden self," and Kapikacchu, which means "one begins scratching like a monkey," are two Sanskrit names for it. Levodopa, often known as L-dopa, is found in high amounts in the seeds of the Mucuna pruriens plant, ranging from four to seven percent. It also includes tryptamines, phenols, and tannins, which can cause hallucinations. Its high L-dopa concentration is the primary rationale for its usage in Parkinson's disease therapy. Seeds of Mucuna pruriens was procured locally, authenticated by Professor, Department of Botany, by the studies include organoleptic tests, macroscopic and microscopic observations were done. The animal used for the work were Healthy wister rats(male) weighing about 150-200g used for the study were procured from local animal house.