Abstract
Activity-dependent immobilization of mitochondria: the role of Miro
Highlights
It is well established that in neurones, at any one time, in the range of 13–30% of the mitochondrial population are mobile moving in both anterograde and retrograde directions utilising motor proteins and the microtubule network
It has a short C-terminal domain that is located inside mitochondria, one transmembrane domain and within the N-terminal region which protrudes from the mitochondria into the cell cytoplasm, it has two GTPase domains, I and II, which are separated by two EF-hand calcium binding domains, EF-hands I and II
MacAskill et al (2009) showed that over-expression of green fluorescent protein (GFP)-Miro1 resulted in ∼ 20% increase of mobile mitochondria with no change in neither their density nor average velocity
Summary
It is well established that in neurones, at any one time, in the range of 13–30% of the mitochondrial population are mobile moving in both anterograde and retrograde directions utilising motor proteins and the microtubule network. The focus of MacAskill et al (2009) is the mitochondrial protein, Miro1, and its role on the mobility of dendritic mitochondria in primary cultures of hippocampal neurones. It is known that anterograde mitochondrial transport is mediated via interaction with kinesin motor proteins.
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