Abstract
Osmotic and activity coefficients of amphiphilic drugs chlorpromazine hydrochloride and promethazine hydrochloride in aqueous solutions have been derived from vapor pressure measurements, in the presence of low concentrations of added electrolyte (0.000, 0.010, 0.025, and 0.050 mol kg-1 NaCl) at the temperature 303.15 K. From these results an inflection point was detected for both phenothiazine drugs identified as a critical concentration.
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