Activity and gene expression of transglutaminase in guinea pig liver during the postnatal growing phase

Abstract

During the postnatal growing phase from birth to 7 weeks old, the cytosolic transglutaminase activity of guinea pig liver increased 3.8-fold. The enzyme activity in the particulate fraction increased slightly. Immunoblot analyses showed that the postnatal increase in the activity was correlated with an increase in the enzyme protein. The quantity of mRNA of the liver transglutaminase did not change significantly during the postnatal growing phase examined. These results indicated that transglutaminase may be involved in the postnatal development of guinea pig liver and that the amount of transglutaminase in the postnatal liver may be controlled post-transcriptionally.