Abstract
Fumaria capreolata is used in traditional medicine for its gastrointestinal, hepatoprotective, and antiinflammatory activities. The aim of the present study was to investigate the anti-inflammatory and the analgesic effects of the ethanolic extract of Fumaria capreolata (EFC) in mice. Anti-inflammatory activity was evaluated by using the xylene-induced ear edema and multi-application of TPA induced chronic inflammation, whereas acetic acid-induced abdominal constrictions and formalin-induced licking and biting were used to determine antinociceptive effects. The crud extract of Fumaria capreolata (500 and 250 mg/kg) produced a significant inhibition of ear edema in two models of acute and chronic inflammation, and produced a significant reduction of the number of writhes. Also, in the formalin test, EFC reduced both neurogenic and inflammatory phases. These findings suggest the aerial parts of Fumaria capreolata exhibits potent anti-inflammatory and analgesic activities on chemical behavioral models of nociception and inflammation in mice.
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