Abstract
Activities of pyruvate and propionyl CoA carboxylase in chicken tissues during normal growth and biotin deficiency were investigated.In normal growing chickens, liver and kidney pyruvate carboxylase activity was high and varied with age. The activity in heart and brain was low and remained relatively constant throughout the experimental period. Propionyl CoA carboxylase activity in kidney and heart appeared to increase with age but remained unchanged in liver and brain.Biotin deficiency progressively decreased both pyruvate and propionyl CoA carboxylase activities in liver, kidney, heart and brain. Most marked effects were observed in liver and kidney.
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