Abstract
The activities of hepatic vitamin B 6 metabolizing enzymes and the concentrations of vitamin B 6 vitamers in plasma and liver were studied in uremic rats. The uremic group of rats was prepared by a two-stage surgical procedure. Food intake of the control and uremic groups was not significantly different. The loss of renal function of the uremic rats was evident by the significantly decreased creatinine clearance value as well as the elevated serum urea levels. Concentrations of each liver B 6 vitamer and plasma total vitamin B 6 were not significantly different between the control and uremic groups. Plasma pyridoxal 5′-phosphate concentrations were 31% ( P P 6 in the uremic rats resulted from the significantly elevated plasma pyridoxal levels. Based on the results of this study, plasma total vitamin B 6 would apparently not be an appropriate biochemical index for assessing vitamin B 6 status in chronic renal disease.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
