Abstract
The activity of enzymatic defences against free radical attack including superoxide dismutase (SOD), catalase, glutathione peroxidase and glutathione reductase have been compared in some experimental animal tumours with the corresponding normal mouse tissues. The activity of SOD in PC6 plasmacytoma and P388 lymphocytic leukaemia was lower than in normal lymphocytes and the activity in a mouse bladder carcinoma (MB) was one-half of that of the normal bladder tissue. Similarly PC6, P388, TLX5 lymphoma and MB showed lower catalase activity than the corresponding normal tissues. The activity of glutathione peroxidase in tumours was in general comparable with that of the normal tissues with the exception of MB, while TLX5, PC6 and P388 contained much lower glutathione reductase activity than normal lymphocytes. The results suggest that it may be possible to selectively destroy certain tumours by peroxidative attack, and that P388 leukaemia would be much more sensitive than L1210 leukaemia to free radical production.
Highlights
Sununary The activity of enzymatic defences against free radical attack including superoxide dismutase (SOD), catalase, glutathione peroxidase and glutathione reductase have been compared in some experimental animal tumours with the corresponding normal mouse tissues
Several enzymes have evolved to cope with 02- produced by metabolic reactions in cells in an oxygen environment. (a) Superoxide dismutase (SOD) which converts 02 to H202 and °2- (b) Catalase which serves to reduce the H202 to H20. (c) Glutathione peroxidase which acts complementarily to catalase in elimination of H2 02 especially in tissues or compartments devoid of catalase. (d) Glutathione reductase which catalyzes the reduction of the oxidized form of glutathione produced by glutathione peroxidase by reduced pyridine nucleotides
This study compares the total cellular activity of SOD, catalase, glutathione peroxidase and glutathione reductase in experimental animal tumours of peripheral tissues with that found in normal host tissues, some of which are susceptible to the cytotoxicity of current chemotherapeutic agents, as a preliminary investigation of the ability of neoplastic tissues to deal with free radical attack
Summary
Sununary The activity of enzymatic defences against free radical attack including superoxide dismutase (SOD), catalase, glutathione peroxidase and glutathione reductase have been compared in some experimental animal tumours with the corresponding normal mouse tissues. (d) Glutathione reductase which catalyzes the reduction of the oxidized form of glutathione produced by glutathione peroxidase by reduced pyridine nucleotides Some deficiencies in these free radical detoxification enzymes have been shown in tumour tissues. This study compares the total cellular activity of SOD, catalase, glutathione peroxidase and glutathione reductase in experimental animal tumours of peripheral tissues with that found in normal host tissues, some of which are susceptible to the cytotoxicity of current chemotherapeutic agents, as a preliminary investigation of the ability of neoplastic tissues to deal with free radical attack
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
