Abstract
Objectives To investigate whether there are changes in the activity of the enzymes NTPDase, 5′-nucleotidase, E-NPP and ADA in platelets from patients with rheumatoid arthritis (RA). Design and methods Thirty-five RA patients diagnosed with RA through American College of Rheumatology criteria, as well as 35 healthy patients were selected. NTPDase, 5′-nucleotidase, E-NPP and ADA activities were verified in platelets isolated from these patients. Results The results demonstrate that an increase in NTPDase (approximately 100%), 5′-nucleotidase (170%), E-NPP (approximately 100%) and ADA (approximately 45%) activities occurred in RA patients when compared to the control group. Conclusions Ours results suggest an increase in the NTPDase, 5′-nucleotidase and E-NPP activities, which could be related to a compensatory organic response to excessive platelet aggregation which occurs during the inflammation. The increased ADA activity found in this work could lead to a decrease in the adenosine concentration in the circulation, which could explain the accelerated atherosclerosis found in patients with RA.
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