Abstract
5-methylfurfuryltrimethylammonium iodide (5-methylfurmethide), a furan analog of muscarine with high muscarinic activities, stimulated frog rectus muscle in a dose dependent fashion with an ED50 of 2.46 M. Physostigmine treatment did not influence the dose-response curve. Repeated exposure of the preparation to a high dose of 5-methylfurmethide (10 −2 M) indicated that: 1) 5-methylfurmethide desensitizes the cholinergic receptors, and 2) the onset of desensitization to the agent and acetylcholine is faster than the recovery. Our results suggest that an appropriate explanation of the desensitization caused by 5-methylfurmethide may require an in depth study of the onset and recovery of the process.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
