Abstract
The mission of the Universal Protein Resource (UniProt) (http://www.uniprot.org) is to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequences and functional annotation. It integrates, interprets and standardizes data from literature and numerous resources to achieve the most comprehensive catalog possible of protein information. The central activities are the biocuration of the UniProt Knowledgebase and the dissemination of these data through our Web site and web services. UniProt is produced by the UniProt Consortium, which consists of groups from the European Bioinformatics Institute (EBI), the SIB Swiss Institute of Bioinformatics (SIB) and the Protein Information Resource (PIR). UniProt is updated and distributed every 4 weeks and can be accessed online for searches or downloads.
Highlights
Universal Protein Resource (UniProt)’s mission is to facilitate scientific discovery by organizing biological knowledge and enabling researchers to rapidly comprehend complex areas of biology
The four UniProt databases are optimized for different users as follows: the UniProt Knowledgebase (UniProtKB) is an expertly curated database consisting of two sections: a reviewed section containing manually annotated records with information extracted from literature and curatorevaluated computational analysis (UniProtKB/SwissProt), and an unreviewed section with automatically annotated records (UniProtKB/TrEMBL); the UniProt Archive (UniParc) (1) is a comprehensive sequence repository, reflecting the history of all protein sequences in the UniProtKB and in all the source databases; the UniProt Reference Clusters (UniRef) (2), which merge closely related sequences based on sequence identity to facilitate sequence similarity searches; and the UniProt Metagenomic and Environmental Sequence (UniMES) database, which was created to cater for the developing area of metagenomics
Annotation from the automatic annotation systems is labeled with evidence attribution indicating both the system and the specific source rule on both the UniProt Web site and in the XML format of UniProtKB available at http://www. uniprot.org/downloads
Summary
UniProt’s mission is to facilitate scientific discovery by organizing biological knowledge and enabling researchers to rapidly comprehend complex areas of biology. UniProt concentrates its manual annotation effort on annotating experimental data from the literature for reference proteome records and aims to provide high-quality annotation for representative members of all protein families across diverse taxonomic groups.
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