Abstract
Rhamnus alaternus L. (Rhamnaceae) had been the object of number of therapeutic indications in traditional medicine in the Mediterranean area. Our study intends to compare the hepatotoxic effects of two plant extracts especially two aqueous lyophilized extracts (decocted and macerated); all administered to different batch rats initially jaundiced made by injection of the hepatotoxic. The reference antihepatotoxic product used is the silymarine (100 mg/kg). The two extracts (250 mg/kg) had witnessed a significative antihepatotoxic action (p<0,05) expressed by enzymatic biochemical markers reduction percentage, especially the transaminases (ASAT/SGOT; ALAT/SGPT), the alkaline phosphatase (ALP) and direct bilirubine (DBil). The reduction mean percentages of antihepatotoxic activity were: 76,28% (lyophilized decocted); 74,16% (lyophilized macerated); 44,68% (silymarine). These results illustrate the antihepatotoxic pharmacological action of two extracts used of this plant.
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