Active versus passive exploration of virtual environments modulates spatial memory in MS patients: a yoked control study

Abstract

This study investigated whether exploration of computer-generated environments can selectively enhance spatial memory in patients with multiple sclerosis (MS). Fifteen patients and 15 healthy subjects who controlled their movements in a virtual house using a joystick recalled the spatial layout of the environments better than 15 patients and 15 controls who merely watched the active participants' progress. Among passive subjects, only healthy controls did significantly better than active participants in the recall of virtual objects. There were no significant differences between active and passive participants' recall of correct object locations in the virtual environments. MS patients' recall of the spatial layout and of the virtual objects was significantly worse than that of healthy subjects, but patients' data did not correlate with traditional neuropsychological measures of spatial memory. It is suggested that virtual reality can be used in MS patients to assess aspects of spatial memory that are not measured by traditional tests.